Minesapride is a partial agonist with a highly selective serotonin 4 (5-HT4) receptor. Minesapride enhances gastrointestinal peristalsis and colon transport by activating the 5-HT4 receptor. Minesapride increases bowel movements and suppresses visceral allergic reactions. Minesapride can be used in the study of constipation-type irritable bowel syndrome (IBS-C)[1].
References
[1] Fukudo S, et al. Efficacy and safety of 5-HT4 receptor agonist minesapride for irritable bowel syndrome with constipation in a randomized controlled trial[J]. Clinical Gastroenterology and Hepatology, 2021, 19(3): 538-546. e8. DOI:10.1016/j.cgh.2020.03.019
