(S)-BI 665915 (oral; 1-100 mg/kg) demonstrates dose-dependent LTB4 production inhibition in mouse whole blood, 2 h after single oral dose[1].
(S)-BI 665915 (iv of 1 mg/kg or po of 10 mg/kg) shows low iv plasma clearance in all three species, with clearance values of 7 % Qh in rat, 2.8 % Qh in dog, and 3.6 % Qh in cynomolgus monkey, respectively. The volume of distribution (Vss) across species tested is in a range of 0.5 to 1.2 L/kg, and the bioavailability was good (45 to 63 %) in all species tested[1].
| Animal Model: | C57BL/6 mice[1] |
| Dosage: | 1, 3, 10, 30, 100 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral |
| Result: | Demonstrated dose-dependent LTB4 production inhibition in mouse whole blood, 2 h after single oral dose.
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| Animal Model: | Rat; dog; cynomolgus monkey[1] |
| Dosage: | 1 mg/kg (iv) or 10 mg/kg (po) |
| Administration: | Iv or po |
| Result: | Showed low iv plasma clearance in all three species, with clearance values of 7 % Qh in rat, 2.8 % Qh in dog, and 3.6 % Qh in cynomolgus monkey, respectively.
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