1414854-44-6

Name	Verosudil Hydrochloride
CAS	1414854-44-6
Molecular Formula	C17H18ClN3O2S
Molecular Weight	363.862
MOL File	1414854-44-6.mol

Synonyms

AR 12286 hydrochloride Verosudil Hydrochloride N-(1,2-Dihydro-1-oxo-6-isoquinolinyl)-alpha-(dimethylamino)-3-thiopheneacetamide hydrochloride

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Hazard Information

Uses

Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is an inhibitor for Rho-kinase (ROCK) with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

IC 50

ROCK1: 2 nM (Ki); ROCK2: 2 nM (Ki)

References

[1] Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. DOI:10.1089/jop.2017.0023
[2] Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. DOI:10.1136/bjophthalmol-2012-302466

Supplier

Beijing xinyanhui pharmaceutical research and development co., LTD

Telephone 13969155946

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList710437/0_EN.htm

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Telephone 1701086315

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList182151/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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