Description
RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase and cAMP-dependent kinase.
Uses
RG 14921 is a compound structurally related to Erbstatin (HY-113549) and has inhibitory activity against EGFR tyrosine kinase and CAMP-dependent kinase activity. RG 14921 inhibits EGF receptor kinase activity as a noncompetitive inhibitor.
References
[1] INHIBITION KINETICS AND SELECTIVITY OF THE TYROSINE KINASE INHIBITOR ERBSTATIN AND A PYRIDONE-BASED ANALOGUE
