1628224-94-1

Name	3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one
CAS	1628224-94-1
Molecular Formula	C18H19ClN4O2S
Molecular Weight	390.89
MOL File	1628224-94-1.mol

Synonyms

EOS-62164 Thrombin inhibitor 6 3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one 2(1H)-Pyridinone, 3-[5-[[(5-chloro-2-thienyl)methyl]amino]-1-(2,2-dimethyl-1-oxopropyl)-1H-pyrazol-3-yl]-

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Chemical Properties

density	1.38±0.1 g/cm3(Predicted)
pka	10.30±0.10(Predicted)

Hazard Information

Uses

Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].

in vivo

Thrombin inhibitor 6 (compound 73) (9 mg/kg, i.v.) prolongs the tail bleeding time in CD-1 mice^[1].
Thrombin inhibitor 6 (5 mg/kg, p.o.) shows F(%) of 22.8%, AUC of 713.3 h.ng/mL and C_max of 127 ng/mL in male CD-1 mice^[1].

Animal Model:	CD-1 mice^[1]
Dosage:	9 mg/kg
Administration:	Intravenous injection (i.v.)
Result:	The mice bled for 25 min following transection. Led to 1.5-fold increase of liberated whole blood cells.

References

[1] Short KM, et al. Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors. Eur J Med Chem. 2022 Oct 27;246:114855. DOI:10.1016/j.ejmech.2022.114855

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TargetMol Chemicals Inc.

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