1661838-94-3

Name	L-Proline, compd. with 2-[(4-cyclopropylphenyl)methyl]-4-β-D-glucopyranosylbenzonitrile, hydrate (1:1:1)
CAS	1661838-94-3
Molecular Formula	C28H34N2O7
Molecular Weight	510.59
MOL File	1661838-94-3.mol

Synonyms

Velagliflozin proline hydrate Velagliflozin L-proline Monohydrate L-Proline, compd. with 2-[(4-cyclopropylphenyl)methyl]-4-β-D-glucopyranosylbenzonitrile, hydrate (1:1:1)

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Chemical Properties

form	Solid-Liquid Mixture
color	White to light yellow

Hazard Information

Uses

Velagliflozin proline hydrate is the clinical form of Velagliflozin (HY-109018). Velagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations[1].

in vivo

Velagliflozin proline hydrate (1 mg/kg; p.o.; single dose) increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats^[1].
Velagliflozin proline hydrate (0.3 mg/kg; p.o.; once daily for 18 d) is well tolerated and can improve insulin disorders and prevent laminitis in ponies by reducing the high insulin response of dietary non-structural carbohydrates (NSC)^[2].

IC 50

SGLT2

References

[1] Hoenig M, et al. Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther. 2018 Apr;41(2):266-273. DOI:10.1111/jvp.12467
[2] Meier A, et al. The sodium-glucose co-transporter 2 inhibitor velagliflozin reduces hyperinsulinemia and prevents laminitis in insulin-dysregulated ponies. PLoS One. 2018 Sep 13;13(9):e0203655. DOI:10.1371/journal.pone.0203655

Supplier

Suzhou Haiben Pharmaceutical Co., Ltd

Telephone19353112242

Website

Nantong Hanfang Biotechnology Co. , Ltd.

Telephonehanfangpharma@126.com; 18616537568

Websitehttps://hanfangpharma@126.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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