1708103-69-8

ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1].

ARTD1/PARP1: 9.7 μM (IC₅₀); ARTD10/PARP10: 2.0 μM (IC₅₀); ARTD8/PARP14: >20 μM (IC₅₀); ARTD7/PARP15: >20 μM (IC₅₀)

[1] Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51. DOI:10.1016/j.ejmech.2015.03.067