2126784-39-0

Name	2(1H)-Pyridinone, 1-(4-fluorophenyl)-4-[(2S)-2-phenoxypropoxy]-
CAS	2126784-39-0
Molecular Formula	C20H18FNO3
Molecular Weight	339.36
MOL File	2126784-39-0.mol

Synonyms

2(1H)-Pyridinone, 1-(4-fluorophenyl)-4-[(2S)-2-phenoxypropoxy]-

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Chemical Properties

Boiling point	519.9±50.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)
form	Solid
pka	-1.25±0.63(Predicted)
color	Off-white to light yellow

Hazard Information

Description

VU 6010572 is a negative allosteric modulator (NAM) for mGlu. VU 6010572 has an IC50 of 245 nM for mGlu3 with high selectivity among all mGlu receptors. VU 6010572 is highly CNS penetrant.

Uses

VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2].

in vivo

VU6010572 (3 mg/kg; i.p.) shows robust efficacy^[1].
VU6010572 (3 mg/kg; i.p.; 45 minutes) produces lasting anxiolytic-like behavioral effects^[2].

Animal Model:	CD-1 mice^[1]
Dosage:	3 mg/kg
Administration:	I.p.
Result:	Showed robust efficacy.

Animal Model:	Rats^[2]
Dosage:	3 mg/kg
Administration:	I.p.; 45 minutes
Result:	Produced lasting anxiolytic-like behavioral effects.

IC 50

mGluR3: 245 nM (IC₅₀)

References

[1] Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15. DOI:10.1021/acsmedchemlett.7b00249
[2] Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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