2241017-37-6

Isonicotinaldehyde 2-pyridin is an antileishmanial agent that is effective against the promastigotes of L. amazonensis and L. braziliensis. Isonicotinaldehyde 2-pyridin has no significant toxic effects on mouse macrophages. The biological activity of Isonicotinaldehyde 2-pyridin is closely related to increasing reactive oxygen species (ROS) and interfering with parasite mitochondrial function. Isonicotinaldehyde 2-pyridin showed its effects on L. amazonensis in preliminary studies on its pharmacological mechanism of action[1].

[1] Synthesis, Biological Activity, and Mechanism of Action of 2-Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents