2366264-18-6

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 μM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].

JNK1: >100 μM (IC₅₀); JNK2: >100 μM (IC₅₀); JNK3: 0.25 μM (IC₅₀)

[1] Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445. DOI:10.1016/j.ejmech.2020.112445