2402779-21-7

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 μg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 μg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

SIRT1: 1.81 μg/mL (IC₅₀); SIRT2: 2.10 μg/mL (IC₅₀); SIRT3: 20.5 μg/mL (IC₅₀)

[1] Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926. DOI:10.1016/j.ejmech.2019.111926