2519631-11-7

COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].

COX-2: 0.039 μM (IC₅₀); COX-1: 12.4 μM (IC₅₀)

[1] Labib MB, et al. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study. Bioorg Chem. 2020 Nov;104:104308. DOI:10.1016/j.bioorg.2020.104308