2956426-18-7

Uses

MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model[1].

in vivo

MAO-B-IN-21 (30 mg/kg; ig; single dose) could cross the BBB easily in Balb/C mice^[1].
MAO-B-IN-21 (8 mg/kg and 32 mg/kg; ig; single dose) shortenes the escape latency time (ELT), reduced Aβ_1-42 level, indicating the improvement in learning and memory ability in Aβ-induced AD mice model^[1].

Pharmacokinetic Analysis in Balb/C mice^[1]

Tissue	T_1/2	T_max	C_max	AUC_0-t	AUC_brain/plasma
Plasma	1.15 h	0.5 h	1539 ng/mL	2941 ng·h/mL	0.69
Brain	2.07 h	1.0 h	922.7 ng/g	2032.5 ng·h/g

IC 50

MAO-B

References

[1] Cong S, et al. Discovery of novel 5-(2-hydroxyphenyl)-2-phthalide-3(3H)-pyrazolones as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115216. DOI:10.1016/j.ejmech.2023.115216

Hazard Information

Uses

in vivo

IC 50

References

Supplier