ChemicalBook CAS DataBase List 30484-77-6

30484-77-6

Name	Flunarizine dihydrochloride
CAS	30484-77-6
EINECS(EC#)	250-216-6
Molecular Formula	C26H28Cl2F2N2
MDL Number	MFCD00058198
Molecular Weight	477.42
MOL File	30484-77-6.mol

Synonyms

1-(BIS[4-FLUOROPHENYL]) DIHYDROCHLORIDE 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE 2 HCL 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLO RIDE (E)-1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE DIHYDROCHLORIDE FLUNARIZINE 2HCL FLUNARIZINE DIHYDROCHLORIDE FLUNARIZINE HCL FLUNARIZINE HYDROCHLORIDE (e)-1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazinedihydroch (e)-1-(bis(p-fluorophenyl)methyl)-4-cinnamylpiperazinedihydrochloride 1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-,dihydrochloride,(e)-piperazin kw-3149 r14950 Flunarizine, DiHCl (E)-1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride FLUNARIZINE DIHYDROCHLORIDE CA2+/NA+ CHA NNEL ANTA FLUNARIZIN-DIHYDROCHLORIDE FLUNARIZINE HYDROCHLORIDE EPF(CRM STANDARD) Flugeral Flunarl

Chemical Properties

Melting point	188-190?C
storage temp.	2-8°C
solubility	chloroform/methanol (9:1): 50 mg/mL, clear, colorless
form	neat
color	White to Off-White
Merck	13,4170
BRN	4284243
InChI	InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChIKey	RXKMOPXNWTYEHI-RDRKJGRWSA-N
SMILES	C(C1C=CC(F)=CC=1)(C1=CC=C(F)C=C1)N1CCN(C/C=C/C2C=CC=CC=2)CC1.Cl.Cl
CAS DataBase Reference	30484-77-6(CAS DataBase Reference)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. less more
WGK Germany	3
RTECS	TK9187000
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Solid

Originator

Sibelium,Janssen,W. Germany,1977

Uses

antipsychotic, H1 antihistamine

Uses

Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.

Definition

ChEBI: Flunarizine hydrochloride is a diarylmethane.

Manufacturing Process

A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.

Therapeutic Function

Vasodilator

General Description

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

Biological Activity

Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Biochem/physiol Actions

Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells

storage

Store at -20°C

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Shanxi Zhendong Ante Biological Pharmaceutical Co., Ltd.

Telephone0354-2467987

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList213255/0_EN.htm

Shanghai Boyle Chemical Co., Ltd.

Telephone 021-50182298 021-50180596

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone18210857532; 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Energy Chemical

Telephone021-021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Adamas Reagent, Ltd.

Telephone400-6009262 16621234537

Websitehttp://www.tansoole.com

ShengXiong Biological Technology Development Co., Ltd.

Telephone86-021-64960112 13774219177

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList14288/0_EN.htm

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone15527621225; 15527621225

Websitehttp://www.farchem.com/

China Langchem Inc.

Telephone0086-21-58956006

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm

Hangzhou Yuhao Chemical Technology Co., Ltd

Telephone0571-82693216

Websitehttp://www.chemyuhao.com

Spectrum Chemical Manufacturing Corp.

Telephone021-021-021-67601398-809-809-809 15221380277

Websitehttps://www.spectrumchemical.com/OA_HTML/index.jsp?minisite=10020&respid=22372&language=US

Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

Websitehttp://www.meilunbio.com/

Shanghai civi chemical technology co.,Ltd

Telephone86-21-34053660

Websitehttp://www.labgogo.com

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-6206333 13167063860

Websitehttp://www.aladdin-e.com/

1of4

Related Products

Send Inquriy