40851-95-4

Dark green solid

6-Chloro-2-nitropyridin-3-amine (E-23) (8.8 g, 51 mmol, 1.0 eq.) was used as a raw material and mixed with Ruanne nickel (0.88 g) in methanol (100 mL). The reaction mixture was stirred at room temperature for 24 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to afford the target product 6-chloropyridine-2,3-diamine (E-24) (7 g, 95.6% yield) as a pale white solid. The product was detected by ESI-MS, m/z: 144.05 [M + H]+.

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