501081-38-5

Name	FGI-106 (FGI106)
CAS	501081-38-5
Molecular Formula	C28H38N6
MDL Number	MFCD34469341
Molecular Weight	458.64
MOL File	501081-38-5.mol

Synonyms

FGI-106 FGI-106 (FGI106) Quino[8,7-h]quinoline-1,7-diamine, N1,N7-bis[3-(dimethylamino)propyl]-3,9-dimethyl-

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Hazard Information

Uses

FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively[1].

in vivo

FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner^[1].

Animal Model:	Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)^[1]
Dosage:	0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
Administration:	Intraperitoneal injection; treatments on days 2 and 5
Result:	Decreased mortality from Zaire EBOV in a dose-dependent manner.

IC 50

HIV-1

References

[1] Aman MJ, et al. Development of a broad-spectrum antiviral with activity against Ebola virus. Antiviral Res. 2009 Sep;83(3):245-51. DOI:10.1016/j.antiviral.2009.06.001

Supplier

Sichuan Yuehe Bio-Pharmaceutical Co.,Ltd

Telephone028-82729560 18030702676

Websitehttp://www.yuehepharm.com

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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