Aztreonam (lysine) is a monocyclic beta-lactam antibiotic, and has a very high affinity for penicillin-binding protein 3 (PBP-3). Aztreonam (lysine) is active against Gram-negative aerobic bacteria[1][2].
References
[1] Guay DR, et al. Aztreonam, a new monobactam antimicrobial. Clin Pharm. 1985 Sep-Oct;4(5):516-26. PMID:3902330 [2] Brogden RN, et al. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1986 Feb;31(2):96-130. DOI:10.2165/00003495-198631020-00002
