1675206-11-7
中文名称
化合物 T25109
英文名称
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
CAS
1675206-11-7
分子式
C21H21F3N2O3
分子量
406.4
MOL 文件
1675206-11-7.mol
结构式
基本信息
中文别名
化合物 T25109
英文别名
ARN6039
ARN-6039
ARN 6039
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
ARN-6039
ARN 6039
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
应用领域
用途一
ARN-6039 (being developed by Arrien), is a Potent, Orally Available Inverse Agonist of RORgammat for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against ROR?t was demonstrated in a ROR?t-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 release from CD4+T cell assays (220 nM). The compound also possesses ideal CNS drug-like criteria, exhibited excellent pharmacokinetics (%F: 37), pharmacodynamics, and correlative PK/PD and ADME characteristics.
常见问题列表
概述
ARN-6039是一种口服的 RORγ 反向激动剂，用于自身免疫性脱髓鞘疾病。