ChemicalBook CAS数据库列表 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate化学性质

熔点 :170.1-173.4 °C
沸点 :544.1±60.0 °C(Predicted)
密度 :1.48±0.1 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :DMSO: >20mg/mL
形态 :white powder
酸度系数(pKa) :8.26±0.70(Predicted)
颜色 :White to off-white
InChI :1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChIKey :DSLPMJSGSBLWRE-UHFFFAOYSA-N
SMILES :NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1

安全信息

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate性质、用途与生产工艺

生物活性 Irosustat (STX64, BN83495)是一种具有口服活性的、不可逆的类固醇硫酸酯酶 (steroid sulfatase)抑制剂。
靶点
Target Value
STS
() 8 nM
体外研究

Irosustat (667 COUMATE) is a potent steroid sulfatase inhibitor, with an IC ₅₀ of 8 nM. Irosustat (667 COUMATE) inhibits steroid sulphatase (STS) activity in MCF-7 cells with an IC ₅₀ of 0.2 nM, but has no effect on the morphology or proliferation of MCF-7 cells at 10 μM.
体内研究

Irosustat potently inhibits rat liver, with inhibition of >90% when at a 1 mg/kg concentration. Irosustat (2 mg/kg, p.o. for 5 d) blocks the uterine growth stimulated by oestrone sulfate (E1S) in ovariectomized rats. In addition, Irosustat (2, 10 mg/kg, p.o.) plus E1S dose-dependently decreases the growth of NMU-induced mammary tumors in ovariectomized rats. Irosustat (667 COUMATE; 10 mg/kg, p.o.) shows 97.9 ± 0.06% inhibition on steroid sulphatase (STS) activity in rat liver.

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate上下游产品信息

上游原料

下游产品

更新日期：2026/03/03
产品编号：S6558
产品名称：6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat (BN83495)
CAS编号：288628-05-7
包装：5mg
价格：1040.6元

更新日期：2026/03/03
产品编号：S6558
产品名称：6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat (BN83495)
CAS编号：288628-05-7
包装：25mg
价格：3415.97元

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate生产厂家

Target	Value
STS ()	8 nM