Manufacturing Process
4,4-Diaminodiphenylmethane reacted with HNO3 and as a result of this
reaction 4,4-diamino-2,2-dinitro-diphenylmethane was obtained.
By reducing of 4,4-diamino-2,2-dinitro-diphenylmethane with HCl and Sn,
2,2,4,4-tetraaminodiphenylmethane was produced, which at heating to 150°C
gave 3,6-diamino-9,10-dihydroacridine.
The 3,6-diamino-9,10-dihydroacridine by oxidation with FeCl3 was converted
to 3,6-diaminoacridine.
3,6-Diaminoacridine was reacted with acetanhydride and 3,6-bis-
(acetylamino)-acridine was produced.
3,6-Bis-(acetylamino)-acridine was methylated by p-toluolsulfomethyl ether
and 3,6-bis-(acetylamino)-10-methylacridinumtosylate was produced.
Then the 3,6-bis-(acetylamino)-10-methylacridinumtosylate was converted to
3,6-diamino-10-methylacridinum chloride (acriflavinum chloride) by reaction
with hydrochloric acid.
