Uses
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.
References
[1] Rodrigueza WV, Woolliscroft MJ, Ebrahim AS, et al. Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide.Cancer Chemother Pharmacol. 2014;74(1):151-166. DOI:
10.1007/s00280-014-2476-y[2] Westin J, Maris MB, Jacobson CA, et al. Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma.Clin Lymphoma Myeloma Leuk. 2022;22(1):52-59. DOI:
10.1016/j.clml.2021.07.020
