Synthesis
General procedure for the synthesis of 5-bromo-1H-indene from 6-bromo-2,3-dihydro-1H-inden-1-ol: 170 g of 6-bromo-2,3-dihydro-1H-inden-1-ol, 1.2 L of hydroxybenzenesulphonic acid, p-toluenesulphonic acid, and 8 g of catalyst were added to a reaction flask for 3 hours. After completion of the reaction, benzene was removed by distillation. The crude product was purified by fast chromatography to give 148 g of 5-bromo-1H-indene (in the form of coral oil) in 95% yield.
References
[1] Journal of Organic Chemistry, 1984, vol. 49, # 22, p. 4226 - 4237
[2] Patent: JP2016/29040, 2016, A. Location in patent: Paragraph 0059
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 8, p. 1298 - 1307
[4] Journal of Organic Chemistry, 1980, vol. 45, # 26, p. 5312 - 5315
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 12, p. 1657 - 1662
