Description
Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates
S. ratti adult worms from intestine and
S. stercoralis larva from muscle. It inhibits polymerization of microtubules isolated from bovine brain with an IC
50 value of 64.2 μM. Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.
References
[1] GROVE D I. Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice.[J]. The American journal of tropical medicine and hygiene, 1982: 469-476. DOI:
10.4269/ajtmh.1982.31.469[2] PAUL A. FRIEDMAN Edward G P. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin[J]. Biochimica et biophysica acta. General subjects, 1978, 544 3: Pages 605-614. DOI:
10.1016/0304-4165(78)90334-3[3] S A BICALHO Q P O J Leo. Cambendazole in the treatment of human strongyloidiasis.[J]. American Journal of Tropical Medicine and Hygiene, 1983, 32 5: 1181-1183. DOI:
10.4269/ajtmh.1983.32.1181[4] ROSSE* G. Compositions and Methods for the Treatment of Mitochondrial Diseases[J]. ACS Medicinal Chemistry Letters, 2012, 3 12: 954. DOI:
10.1021/ml3002924
