Synthesis
GENERAL METHOD: Potassium phosphate (0.75 mmol) and Catalyst IIe (1 mol%) were added to a mixture of toluene (2.0 mL) and water (100 μL) containing p-bromoacetophenone (0.25 mmol) and cyclo-propylboronic acid (0.5 mmol) under nitrogen protection. The reaction mixture was heated to 100 °C, kept for an appropriate time and then cooled to room temperature. After the reaction was completed, it was diluted by adding water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, concentrated by evaporation and purified by silica gel column chromatography to afford the target product 1-(4-cyclopropylphenyl)ethanone.
References
[1] Tetrahedron, 2012, vol. 68, # 3, p. 900 - 905
[2] Synthetic Communications, 2006, vol. 36, # 1, p. 121 - 128
[3] Patent: WO2015/59618, 2015, A1. Location in patent: Page/Page column 42
[4] Journal of the American Chemical Society, 2016, vol. 138, # 20, p. 6598 - 6609
[5] Patent: WO2016/201168, 2016, A1. Location in patent: Paragraph 0662
