3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID 3-SULFATE DISODIUM SALT HYDRATE

Description

Lithocholic acid 3-sulfate is a metabolite of the secondary bile acid lithocholic acid . It is water soluble and the primary form of lithocholic acid in the bile duct. Lithocholic acid 3-sulfate forms a complex with calcium in vitro. Biliary secretion of lithocholic acid 3-sulfate is increased in a rat model of diabetes induced by streptozotocin .

Uses

Lithocholic Sulfate Disodium Salt is an impurity of Cholic Acid (C432600), a choleretic produced by and isolated from liver cells.

References

[1] S. P. BORRIELLO  R. W O. The metabolism of lithocholic acid and lithocholic acid-3-α-sulfate by human fecal bacteria[J]. Lipids, 1982, 17 7: 477-482. DOI: 10.1007/bf02535328
[2] D G OELBERG. Calcium binding by lithocholic acid derivatives.[J]. American Journal of Physiology, 1984, 247 1 Pt 1: G112-5. DOI: 10.1152/ajpgi.1984.247.1.g112
[3] R B KIRKPATRICK  B G K. Effect of streptozotocin-induced diabetes on bile acid sulfation in male rat liver.[J]. American Journal of Physiology, 1984, 247 3 Pt 1: G226-30. DOI: 10.1152/ajpgi.1984.247.3.g226