177Lu-OncoFAP-DOTAGA (50 nmol/kg - 1 μmol/kg, i.v., single dose) efficiently targets FAP-positive tumors in the SK-RC-52.hFAP xenograft model, with dose-dependent accumulation[1].
| Animal Model: | Xenograft model of humanized FAP renal cancer (SK-RC-52.hFAP) in nude mice[1] |
| Dosage: |
50, 125, 250, 500 nmol/kg, and 1 μmol/kg (in the form of 177Lu-OncoFAP-DOTAGA) |
| Administration: | Intravenous injection (i.v.), single dose |
| Result: | Reached 32% of the injected dose per gram of tumor tissue (ID/g) within 10 minutes and maintained above 20% ID/g for 6 hours. |