Glycine, L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinylglycyl-L-α-glutamyl-L-arginyl-

Uses

Insulin β Chain Peptide (15-23) is one of the earliest antigenic epitopes to which CD8 T-cells respond[1][2][3].

in vivo

References

[1] Amrani A, et al. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature. 2000;406(6797):739-742. DOI:10.1038/35021081
[2] Takaki T, et al. Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4. J Immunol. 2004;173(4):2530-2541. DOI:10.4049/jimmunol.173.4.2530
[3] Wong FS, et al. Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes. Diabetes. 2009 May;58(5):1156-64. DOI:10.2337/db08-0800