Chemical Properties
Pk'5.05. UV maximum absorption (0.1 mol/L hydrochloric acid): 265 nm (ε14000). Sapropterin Dihydrochloride: C9H15N5O32HCl.[69056-38-8]. White crystal or crystalline powder, odorless, slightly acidic taste. Extremely soluble in water, more difficult to dissolve in methanol, very difficult to dissolve in ethanol, a few insoluble in ether. Melting point 245～246°C (decomposition). [α]D25-6.81.(C=0.665, 0.1mol/L hydrochloric acid).UV max absorption(2mol/L hydrochloric acid): 264nm(ε16770).
Uses
Treatment of mild-to-moderate phenylketonuria (PKU).
Definition
ChEBI: Sapropterin is a tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer). It has a role as a coenzyme, a diagnostic agent, a human metabolite and a cofactor.
IC 50
Human Endogenous Metabolite
