Uses
NOD1/2 antagonist-1 (compound 36b) is a potent NOD1/2 (nucleotide-binding
oligomerization domain-like receptor 1/2) dual antagonist, with IC50 values of 1.13 (NOD1) and 0.77 μM (NOD2), respectively. NOD1/2 antagonist-1 has a acceptable T1/2 (67.6 min). NOD1/2 antagonist-1 (compound 36b) can improve the antitumor efficacy of Paclitaxel (PTX)[1].
References
[1] Ma Y, Yang J, Wei X, et al. Nonpeptidic quinazolinone derivatives as dual nucleotide-binding oligomerization domain-like receptor 1/2 antagonists for adjuvant cancer chemotherapy. Eur J Med Chem. 2020;207:112723. DOI:
10.1016/j.ejmech.2020.112723
![7-Quinazolinecarboxamide, 6-(3-chlorophenyl)-3-[2-(3,3-difluoro-1-piperidinyl)-2-oxoethyl]-3,4-dihydro-4-oxo-N-[3-[4-(trifluoromethyl)phenoxy]propyl]- Structure](https://www.chemicalbook.com/CAS/20210305/GIF/2704623-69-6.gif)