2-Pyridinamine, 5-[(2R,5S)-5-methyl-4-propyl-2-morpholinyl]-

Uses

PF-592379 is a potent dopamine D3 receptor agonist with an EC50 of 21 nM.

in vivo

References

[1] Attkins N, et al. Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica. 2010 Nov;40(11):730-42. DOI:10.3109/00498254.2010.514961
[2] Wager TT, et al. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects. ACS Chem Neurosci. 2017 Jan 18;8(1):165-177. DOI:10.1021/acschemneuro.6b00297
[3] Collins GT, et al. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23(3):280-91. DOI:10.1097/FBP.0b013e3283536d21