ERLIN1 ANTIBODY

Source

Rabbit

Reactivity

Human

Background

Erlin-1 and erlin-2 are SPFH domain-containing proteins that belong to the prohibitin family. The N-termal domain of erlin proteins contains ER-targeting sequences responsible for their translocation to the endoplasmic reticulum. In the ER, erlin-1 and erlin-2 specifically associate with the detergent resistant lipid raft microdomain of the membrane. Erlin-1 may be involved in dentritic cell activation and erlin-2 has been shown to regulate the ER-associated degradation pathway by interacting with endogenous substrates and resulting in their polyubiquitination and degradation.

References

[1] Browman, D.T. et al. (2007) Trends Cell Biol 17, 394-402.
[2] Morrow, I.C. and Parton, R.G. (2005) Traffic 6, 725-40.
[3] Browman, D.T. et al. (2006) J Cell Sci 119, 3149-60.
[4] Li, N. et al. (2000) Biochem Biophys Res Commun 279, 487-93.
[5] Pearce, M.M. et al. (2007) J Biol Chem 282, 20104-15.