Uses
Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on ATPase may be due to membrane disruption.
Biological Activity
Bassianin is a fungal metabolite that has been found in Beauveria.1,2 It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts by 81, 58, and 23%, respectively, when used at a concentration of 200 μg/ml.1 Bassianin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.91 and 12.12 μM, respectively.2
References
1.Jeffs, L.B., and Khachatourians, G.G.Toxic properties of Beauveria pigments on erythrocyte membranesToxicon.35(8)1351-1356(1997)
2.Arboleda Valencia, J.W., Gaitán Bustamante, A.L., Jiménez, A.V., et al.Cytotoxic activity of fungal metabolites from the pathogenic fungus Beauveria bassiana: An intraspecific evaluation of beauvericin productionCurr. Microbiol.63(3)306-312(2011)
