Description
PD 173212 is an N-type calcium channel blocker (IC
50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg.
Uses
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.
in vivo
PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1].
References
[1] Hu LY, et al. Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2151-6. DOI:
10.1016/s0960-894x(99)00359-5