5,14-Eicosadienoic acid, 20-hydroxy-, (5Z,14Z)-

Uses

20-5,14-HEDE is an analog of 20-HETE with anti-apoptosis activity. 20-5,14-HEDE can inhibit the increase of caspase-3 expression level and DNA fragmentation in pulmonary artery endothelial cells (BPAECs) under serum starvation conditions, thereby reducing cell apoptosis. 20-5,14-HEDE can be used in the study of cardiovascular diseases[1].

References

[1] Dhanasekaran, et al. "20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 296.3 (2009): H777-H786. DOI:10.1152/ajpheart.01087.2008