ZA7371

Product NameZA7371
CAS1494675-86-3
CBNumberCB93060642
MFC18H21N5O3
MW355.39
MDL NumberMFCD29477419
MOL File1494675-86-3.mol
MSDS FileSDS

Chemical Properties

Boiling point	691.6±55.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 11 mg/mL (30.95 mM)
pka	12.79±0.46(Predicted)
form	A crystalline solid
color	White to off-white
FDA UNII	R3T98GBE3C

ZA7371 Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 19310	1mg	$44	AZ 7371 ≥98%	Buy
Cayman Chemical 19310	5mg	$193	AZ 7371 ≥98%	Buy
Cayman Chemical 19310	10mg	$341	AZ 7371 ≥98%	Buy
Cayman Chemical 19310	25mg	$692	AZ 7371 ≥98%	Buy
AK Scientific 4632DW	25mg	$868	DprE1-IN-1	Buy

ZA7371 Chemical Properties,Usage,Production

Uses

TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs[1][2][3].

in vivo

TBA-7371 (100, 200 mg/kg; oral gavage; twice daily; 4-8 weeks) synergistically exerts bactericidal and fungicidal activity with Bedaquiline (HY-14881) and GSK2556286 (HY-147017) in the BALB/c mouse tuberculosis model^[3].
TBA-7371 (50, 100, 200 mg/kg; oral gavage; twice daily; 8 weeks) significantly reduces bacterial burden in lung tissue after 8 weeks of treatment in the C3HeB/Fe J mouse tuberculosis model^[3].

Animal Model:	Female BALB/c mice (5-6 weeks old, specific pathogen-free) + subacute tuberculosis infection model induced by aerosol of Mycobacterium tuberculosis H37Rv^[3]
Dosage:	100 mg/kg, 200 mg/kg (0.5% carboxymethylcellulose + 0.1% Tween 80)
Administration:	Oral gavage, twice daily (8 h apart), 5 days/week for 4-8 weeks; Combination with Bedaquiline (25 mg/kg) and GSK2556286 (50 mg/kg) (BGA regimen)
Result:	At 100 or 200 mg/kg bid significantly increased bactericidal activity after 8 weeks, with lung CFU counts of 1.48 (200 mg/kg) and 1.78 (100 mg/kg), demonstrating superior sterilizing activity compared to two-drug combinations.

Animal Model:	Female C3HeB/FeJ mice (8-10 weeks old, specific pathogen-free) + chronic tuberculosis infection model with caseous necrotic pulmonary lesions induced by aerosol of Mycobacterium tuberculosis Erdman^[3]
Dosage:	50 mg/kg, 100 mg/kg, 200 mg/kg (0.5% carboxymethylcellulose + 0.1% Tween 80)
Administration:	Oral gavage, twice daily, 5 days/week for 8 weeks
Result:	After 8 weeks, all dose groups showed significant reduction in lung bacterial burden compared to untreated controls. The 100 and 200 mg/kg groups achieved approximately 1.5 log CFU reduction, with dose-dependent efficacy. At 100 mg/kg bid exhibited consistent bactericidal activity, with higher drug retention in caseous lesions at trough concentrations.

References

[1] Gawad J, et al. Decaprenyl-phosphoryl-ribose 2'-epimerase (DprE1): challenging target for antitubercular drug discovery. Chem Cent J. 2018 Jun 23;12(1):72. DOI:10.1186/s13065-018-0441-2
[2] Robertson GT, et al. Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0058321. DOI:10.1128/AAC.00583-21
[3] Li S-Y, et al. Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0156223. DOI:10.1128/aac.01562-23

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32469	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39042	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8616	58

ZA7371

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ZA7371 Chemical Properties,Usage,Production

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