Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility
Chloroform, Methanol
form
Solid
pka
15.22±0.20(Predicted)
color
White to Off-White
Stability
Hygroscopic
Safety Information
Symbol(GHS)
Signal word
Warning
Hazard statements
H302：Harmful if swallowed
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330：Rinse mouth.
P501：Dispose of contents/container to..…
Description
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (R)-LSF is the biologically active isomer of LSF. It is a potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 μM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. (R)-LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits interleukin 12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.
