Colesevelam

$76 - $308

Product nameColesevelam
Cas No182815-44-7
MFC31H66Cl2N4O
MW581.8
EINECS806-925-3

Synonyms

Colesevelam and Colesevelam Hydrochloride;colesevelam hcl API;Colesevelam ;2-Propen-1-amine polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride hydrochloride;Colesevelam USP/EP/BP;Colesevelam USP;Colesevelam HydrochlorideQ: What is Colesevelam Hydrochloride Q: What is the CAS Number of Colesevelam Hydrochloride Q: What is the storage condition of Colesevelam Hydrochloride Q: What are the applications of Colesevelam Hydrochloride;Colesevelam hydrochloride

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Price

3 prices

Brand less more

Sigma-Aldrich TRC
Package less more

10mg 50mg

Clear All Done

Brand	Packaging	Price	Product name
Sigma-Aldrich SML3500	10 mg	$76	Colesevelam hydrochloride
Sigma-Aldrich SML3500	50 mg	$308	Colesevelam hydrochloride
TRC C640095	50mg	$95	ColesevelamHydrochloride(TechnicalGrade)

Properties

storage temp.	Store at -20°C
form	Solid
color	White to light yellow
SMILES	C=CCNCCCCCCCCCC.C=CCNCCCCCC[N+](C)(C)C.NCC=C.ClCC1OC1.[xHCl].[Cl-]

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

Colesevelam hydrochloride was launched as Welchol (formerly known as Cholestagel) in the US for the reduction of elevated levels of serum LDL cholesterol and accordingly, the decrease of the risk of vascular disease in patients with primary hypercholesterolemia. This orally administered cationic hydrogel is a non-absorbable, water-insoluble polymer of an hexanaminium chloride with N-(2-propenyl) decanamine, 2-propen-1-amine hydrochloride and chloromethyloxirane. It acts as a powerful bile acid sequestering agent, this binding and blockage of bile acids having the end result of compelling the removal of LDL cholesterol from the blood stream into the liver. In animals fed with a cholesterol-rich diet for several weeks, colesevelam demonstrated a good maintenance of low serum cholesterol levels, this activity being significantly greater when compared with cholestyramine. In several placebo-controlled studies, this agent decreased total cholesterol levels by 6 to 10% and LDL cholesterol levels by 9 to 20%. Combination therapy with the co-administration of a HMG-CoA reductase inhibitor (or statin) and colesevelam produced an additional reduction of 8-16% in LDL-cholesterol levels above that obtained with the statin alone. Due to its unique water-absorbing hydrogel formulation, this polymer is not absorbed at all from the GI tract, and thus, it is said to have a lower rate of side-effects (as the constipating effect) than the previously marketed bile acid sequestrants. Colesevelam hydrochloride may be used as a monotherapy or as a dual therapy with statins.

Related product price

Sevelamer hydrochloride $90-324 CHOLESTYRAMINE RESIN $220-1280 Fosaprepitant dimeglumine $5-4990

Suppliers and manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

$0.00/1g

Colesevelam Hydrochloride

CAS:182815-44-7
career henan chemical co

$1.00/1KG

Colesevelam

CAS:182815-44-7
TargetMol Chemicals Inc.

$40.00/10mg

Colesevelam Hydrochloride

CAS:182815-44-7
RongNa Biotechnology Co.,Ltd

Colesevelam

CAS:182815-44-7
Henan Tianfu Chemical Co.,Ltd.
BOC Sciences
TopScience Biochemical
CONIER CHEM AND PHARMA LIMITED
Xi'an MC Biotech, Co., Ltd.
Shaanxi Dideu Medichem Co. Ltd

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