Methanone, [4-(2-amino-5-chlorophenyl)-1-piperazinyl]tricyclo[3.3.1.13,7]dec-1-yl-

Chemical Properties

Boiling point	577.9±50.0 °C(predicted)
Density	1.296±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	6.66±0.10(predicted)

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Animal Model:	High fat diet (HFD)-induced C57BL/6J obese (DIO) mice^[1]
Dosage:	100 mg/kg
Administration:	Oral administration; 100 mg/kg once
Result:	Decreased blood triglyceride, total cholesterol and low-density lipoprotein cholesterol levels of DIO mice after treatment for 3 week. Significantly decreased the serum alanine aminotransferase (ALT) level and promoted cholesterol excretion after treatment for 45 days. Increased the expression of Srebp1c, stearoyl-CoA desaturase 1 (Scd1), fatty acid synthetase (Fasn), Diac ylgycerol Acyltransferase 2 (Dgat2), 3 Hydroxy-3-methylglutaryl Coenzyme A Reductase (Hmgcr) and sterol regulatory element binding protein 2 (Srebp2). Improved insulin sensitivity of DIO mice. Reduced mRNA levels of interleukin 1 beta (Il-1β), Il5, Il6, cluster of differentiation 36 (Cd36), inducible nitric oxide synthase (iNOS) and mouse EGF-like module-containing mucin-like hormone receptor-like 1 (F4/80).