diethyl 12-bromodecylphosphonate contains bromine and phosphonate moieties. The bromine is a good leaving group and can undergo nucleophilic substitutions. The phosphonate group acts as chelating agent.
Uses
Diethyl 12-bromododecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
Alkyl-Chain
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
