Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects[1][2].
Secoisolariciresinol diglucoside ((S,S)-SDG), the major lignan in whole wheat flaxseed, has anti-inflammatory, antioxidant, anti-mutagenic, antimicrobial, anti-obesity, hypolipidemic and neuroprotective effects.
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals.
Secoisolariciresinol diglucoside (4 mg/mouse; a single po) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.
| Animal Model: < /td> | Hand feeding mice (10 weeks old, male) are injected with TNFα |
| Dosage: | 4 mg/mouse |
| Administration: | Po 2 h before ic administration of TNFα |
| Result: | Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%. |
[1] Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8. DOI:
10.1016/j.bmcl.2013.07.062[2] Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25. DOI:
10.1186/s12974-018-1065-0
