A nitric oxide (NO) scavenger. Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2–/NO3–. In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4
Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)
A water soluble, stable organic free radical that reacts stoichiometrically with NO. Carboxy-PTIO converts NO to NO2 and does not dramatically affect other NO related metabolites. This scavenger allows for the specific investigation of the effect of NO.
Carboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.
ChEBI: Potassium 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide is a potassium salt having 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide as the counterion. It has a role as a radical scavenger and an apoptosis inhibitor. It is a potassium salt and an organic radical. It contains a carboxylato-PTIO.
2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO) is mainly considered as a scavenger of nitric oxide(NO).
A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N( ω )-nitroarginine or N-methylarginine.
Carboxy-PTIO can make a quick reaction with nitric oxide(NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.
[1] TAKAAKI AKAIKE. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.bul.NO (nitric oxide) through a radical reaction[J]. Biochemistry Biochemistry, 1993, 32 3: 827-832. DOI:
10.1021/bi00054a013[2] YOSHIDA M. Therapeutic Effects of Imidazolineoxyl N-Oxide Against Endotoxin Shock through Its Direct Nitric Oxide-Scavenging Activity[J]. Biochemical and biophysical research communications, 1994, 202 2: Pages 923-930. DOI:
10.1006/bbrc.1994.2018[3] MEGUMI HADA F A C Premkumar B Saganti. Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts.[J]. ACS Applied Materials & Interfaces, 2019. DOI:
10.3390/ijms20184327[4] FUJUN JIN . A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells[J]. European journal of pharmacology, 2020, 885: Article 173497. DOI:
10.1016/j.ejphar.2020.173497
