2-Chloro-4-(trifluoromethyl)pyrimidine

Colourless Liquid

2-Chloro-4-(trifluoromethyl)pyrimidine may be used to investigate the effect of chemical substitutions on the interfacial interactions of pyrimidines with the phospholipid-mimic immobilized-artificial-membrane (IAM) chromatographic stationary phase. Monocyclic pyrimidine nucleic acid bases (nucleobases) were reported to behave differently from their bicyclic purine analogs.

2-Chloro-4-(trifluoromethyl)pyrimidine is a pyrimidine derivative. Its density and refractive index have been determined.

First, ethyl trifluoroacetoacetate and urea are refluxed for 4 hours in an ethanol-hydrochloric acid system, and the mixture is cooled to precipitate 2-hydroxy-4-(trifluoromethyl)pyrimidine (intermediate, with a purity of about 95%). Then the intermediate is mixed with phosphorus oxychloride (POCl₃) with 1 drop of DMF as a catalyst, and the reaction is carried out at 80-120 °C for 2-6 hours. After recovering the excess POCl₃, the reaction solution is quenched by pouring into ice water, followed by extraction with ethyl acetate, drying and vacuum distillation (collecting the fraction at 60 °C/10 mmHg) to obtain 2-chloro-4-(trifluoromethyl)pyrimidine, with an overall yield of about 70%.