ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].
ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1].
| Animal Model: | Female athymic nude mice, A549 xenograft model[1] |
| Dosage: | 10, 50, 75 and 100 mg/kg |
| Administration: | Oral gavage, once
|
| Result: | Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion. |
ALK5: ≤10 nM (IC50); ALK2
[1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
![2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Structure](/CAS/20210305/GIF/2785430-89-7.gif)
