DIETHYL(3-PYRIDYL)BORANE

White to yellow solid

suzuki reaction

Reactant for:

• Preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
• N-Methylation reactions of the pyridyl group
• Palladium catalyzed amination reactions
• Intramolecular Heck reactions
• Coupling reactions
• Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling

Reactant for: preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents, N-Methylation reactions of the pyridyl group, Palladium catalyzed amination reactions, intramolecular Heck reactions, Coupling reactions and Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.

reagent type: reductant

Reaction temperature 0 ~ 5 , reaction time 6h, diethylmethoxyborane drop time 30 min, material ratio n (3-bromopyridine): n (diethylmethoxyborane) for 0.9:1.0, material ratio n (isopropylmagnesium chloride): n (diethylmethoxyborane) for 1.0:1.0. In the optimal conditions of the process to produce the product is a white solid, melting point of 172 ~ 175 , yield of more than 81%. Under the optimal process conditions, the product is white solid with a melting point of 172175 and a yield of more than 81%.