Benzamide, 3,5-dichloro-N-[5-[(diethylamino)sulfonyl]-3-(dimethylamino)-2-methoxyphenyl]-4-hydroxy-

JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

[1] Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129(5):1533-1543. DOI:10.1053/j.gastro.2005.07.053