methyl phenothiazin-10-yl ketone

92-84-2

75-36-5

1628-29-1

1. 20 g (0.1 mol) of phenothiazine and 200 mL of toluene are added to a 500 mL flask. 2. 14.3 mL (2 equiv.) of acetyl chloride was added slowly and dropwise to the flask. 3. The reaction mixture was stirred at 50 °C for 1 h to ensure complete reaction. 4. Upon completion of the reaction, the mixture was concentrated to dryness. 5. The resulting precipitate was dissolved in a minimal amount of isopentane followed by filtration. 6. After drying, 24 g of a beige solid product, 1-(10H-phenothiazin-10-yl)ethanone, was obtained in quantitative yield. 7. The product had a melting point of 2.0%. 7. The melting point of the product was 210-211 °C. The product was dried.