依氟鸟氨酸盐酸盐一水合物
依氟鸟氨酸盐酸盐一水合物 性质
| 熔点 | >210°C (dec.) |
|---|---|
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | 溶于水（高达 25 mg/ml）。 |
| 形态 | 白色粉末 |
| 颜色 | 白色 |
| 水溶解性 | water: 1mg/mL methanol: 25mg/mL |
| Merck | 14,3522 |
| 稳定性 | 可在-20°下蒸馏水溶液保存长达3个月。 |
| 主要应用 | pharmaceutical (small molecule) |
| InChI | InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2 |
| InChIKey | FJPAMFNRCFEGSD-UHFFFAOYSA-N |
| SMILES | C(N)(C(=O)O)(C(F)F)CCCN.Cl.O |
| CAS 数据库 | 96020-91-6 |
依氟鸟氨酸盐酸盐一水合物 用途与合成方法
| Target | Value |
| Orn decarboxylase |
用α-difluoromethyl-Orn处理BY2细胞，抑制其过氧化氢的产生，但并没有发生程序性细胞死亡。
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
依氟鸟氨酸盐酸盐一水合物 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-03-03 | 46270 | 依氟鸟氨酸盐酸盐一水合物 | 96020-91-6 | 1g | 311 |
| 2026-03-03 | S4582 | 依氟鸟氨酸盐酸盐一水合物 | 96020-91-6 | 25mg | 794.81 |
