(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT

AH23848 has been used as an prostaglandin E2 receptor 4 (EP4) receptor antagonist to study its effect on cAMP accumulation in monocrotaline (MCT28d) rat pulmonary arterial smooth muscle cells (PASMCs) and human T cell enriched peripheral blood mononuclear cells (PBMC). It has also been used to study its effect on the expressions of collagen-I, metalloproteinase (MMP-1), MMP-3, and EP4 gene expression in human tendon fibroblasts following interleukin (IL)-1β treatment.

ChEBI: (1R,2R,5S)-AH23848 is a (4Z)-7-{5-[([1,1'-biphenyl]-4-yl)methoxy]-2-(morpholin-4-yl)-3-oxocyclopentyl}hept-4-enoic acid in which the stereocentres at positions 1, 2 and 5 have R-, R- and S-configuration respectively. It is a conjugate acid of a (1R,2R,5S)-AH23848(1-). It is an enantiomer of a (1S,2S,5R)-AH23848.

ah 23848 (calcium salt) is a dual antagonist of tp1 and ep4 receptors [1][2].the thromboxane receptor (tp), also known as the prostanoid tp receptor, is activated by thromboxane a2 (txa2). txa2 is an exceptionally potent inducer of platelet aggregation and of contraction of vascular and respiratory smooth muscle [1]. prostaglandin e2 (pge2) subtype receptors (ep) are involved in cellular proliferation and tumor development. prostaglandin e2 (pge2) activates four ep receptors, ep1-4. the ep4 receptor is coupled to gs and mediates increases in camp concentration by activation of adenylyl cyclase [4].ah 23848 (calcium salt) is a dual antagonist of tp1 and ep4 receptors. ah 23848 is an orally active, potent and specific thromboxane receptor-blocking drug that has a long duration of action. ah 23848 inhibited txa2-induced platelet aggregation and antagonized the contraction of human bronchial smooth muscle induced by the tp agonist u-46619 with pa2 of 8.3 [1][3]. in 3t6 fibroblasts, ah-23848b induced accumulation of cells in early s phase and lowered cyclin a levels [4].in syngeneic balb/cbyj female mice injected with line 66.1 or 410.4 tumor cells, ah23848 inhibited the metastasis of line 66.1 and 410.4 cells [5].

AH23848 regulates nitric oxide (NO) production and reduces endogenous cAMP accumulation. This is carried out by declination of inducible nitric oxide synthase (iNOS) gene expression and acceleration of iNOS protein degradation in glomerular mesangial cells.

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