Ceforanide is a second generation cephalosporin with good β-lactamase resistance.
It has a serum half-life of about three hours, allowing twice-daily dosing.
Ceforanide is a cephalosporin based antibiotic used in the sterilization in various medical procedures.
ChEBI: A second-generation cephalosporin antibiotic with {[1-(carboxymethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and 2-(aminomethyl)phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is effective against many col
forms, including Escherichia coli, Klebsiella, Enterobacter and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Ari
ona species.
A semisynthetic parenteral cephalosporin with activity broadly
similar to that of cefalotin. Its activity in vitro is significantly
reduced in the presence of serum. A 1 g intravenous dose achieves a concentration of c. 135 mg/L at the end of infusion.
The response after 0.25, 0.5 and 1 g intravenous doses
is essentially linear. A 1 g intramuscular dose produces mean
peak values of around 70 mg/L. Plasma protein binding is
around 85%.
It is almost entirely eliminated in the urine with a halflife
of about 2.5 h, 80–95% being recovered in the first 12 h.
The half-life is inversely related to renal function, rising
to around 20 h when the creatinine clearance falls below
5 mL/min. About half the dose is removed by hemodialysis
over 6 h.
It is generally well tolerated; phlebitis and pain at the site
of injection are reported in some patients with occasional
transient neutropenia and increased transaminase levels.
It has been used principally for the treatment of infections
due to Gram-positive cocci, including staphylococcal and
streptococcal soft-tissue infections, but is no longer widely
available.
