16,16-DIMETHYL PROSTAGLANDIN A2

16,16-dimethyl PGA₂ is a metabolism-resistant analog of PGA₂ with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-dimethyl PGA₂ methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.

16,16-dimethyl Prostaglandin A2 is a PGA2 analog studied for its antiproliferative properties.

ChEBI: 16,16-dimethyl-PGA2 is a prostanoid.

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